Cyclobenzaprine Flexeril Side Effects & Interactions

Do not use Flexeril if you have taken an MAO inhibitor in the past 14 days. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Immediate medical attention is always needed in cases of overdose.

• Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated.
• Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
• The risk of overdose is significantly increased when Flexeril is combined with other drugs, particularly alcohol or Benzodiazepines.

The drug compounds the effects of substances like painkillers and alcohol, increasing the risk of overdose. Therefore it is essential to follow instructions carefully when taking Flexeril and contact a healthcare professional immediately if any signs of distress or unexpected health changes occur. Yes, you can overdose on Flexeril — including cyclobenzaprine 10 mg dose. Some skeletal muscle relaxants (e.g., carisoprodol) have sedative properties so people may attempt to misuse a drug like cyclobenzaprine thinking that it will have similar sedating effects. Cyclobenzaprine (Flexeril) is structurally similar to TCAs and, as such, demonstrates significant anticholinergic side effects.

What should I do if I forget a dose?

Observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required. Monitoring of plasma drug levels should not guide management of the patient. Dialysis is probably of no value because of low plasma concentrations of the drug. At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats. Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose.

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A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with flexeril schedule controlled substances 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). These patients are generally more susceptible to drugs with potentially sedating effects, including cyclobenzaprine.

What are the side effects of Cyclobenzaprine (Flexeril)?

Cyclobenzaprine acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of this medicine’s side effects. It is available in immediate-release tabletsof 5 milligrams, 7.5 milligrams, and 10 milligrams and extended-release capsules of 15 milligrams and 30 milligrams and is usually given three times daily. The extended-release formulation should be administered at the same time each day. The capsule may be swallowed whole, but its contents also may be sprinkled onto a tablespoon of applesauce for immediate consumption without chewing the granules.

Drug dependence can form even when a drug is taken for medical reasons and used exactly as prescribed. Narcotic drugs, like opioids, and sedatives, like benzodiazepines and tricyclic antidepressants (which are similar in structure to cyclobenzaprine), can cause physical dependence. It’s important to share a complete list of medications and allergies with your doctor before taking any new medicines, including cyclobenzaprine. You shouldn’t combine this muscle relaxer with another sleep aid or alcohol. Because cyclobenzaprine also causes drowsiness, it can intensify the effects of alcohol and other sleeping pills, causing dangerous side effects.

Drowsiness, dizziness, dry mouth, constipation, or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. The dosage is based on your medical condition and response to treatment. This medication should only be used short-term (for 3 weeks or less) unless directed by your doctor. Overdose symptoms may include severe drowsiness, vomiting, fast heartbeats, tremors, agitation, or hallucinations.

Cyclobenzaprine Interactions with Other Substances

Meditation and mindfulness are two great ways to destress, slow down racing thoughts, and reduce anxiety while also relieving muscle tension – especially in the neck, back, and shoulders. Meditate for 5 to 10 minutes each morning, before going to bed, or both. Journaling at night can also help purge anxious thoughts and better prepare you for sleep.

The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems.

If additional types of substance dependence (e.g., alcohol, opioids, sedatives) are a factor, medical detox may be needed. Severe CNS depression may result in significantly slowed breathing, over sedation, coma, and death.3 If you are unable to stop abusing one or more substance, it’s time to seek help. Admitting your substance use has gotten out of control can save your life. This medicine may cause some people to have blurred vision or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and able to see well.